A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron.

نویسندگان

  • Laïla Gannoun-Zaki
  • Amy Jost
  • Jianbing Mu
  • Kirk W Deitsch
  • Thomas E Wellems
چکیده

Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting promoter activation does not affect the transcription of chromosomal var genes.

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عنوان ژورنال:
  • Eukaryotic cell

دوره 4 2  شماره 

صفحات  -

تاریخ انتشار 2005